MeSH Diffuse Cutaneous Allergic Reaction to Dermabond, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, Department of Physical Medicine and Rehabilitation, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaUSA, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsUSA, https://doi.org/10.1017/S1049023X14001010, Get access to the full version of this content by using one of the access options below. Bowen, C, Bidinger J, Hivnor C, Hoover A, Henning J (2014) Allergic contact dermatitis to 2-Octyl cyanoacrylate. Alotaibi, Nawaf Naif (2020). Lindstrom I, Suojalehto H, Henriks-Eckerman ML, Suuronen K (2013) Occupational asthma and rhinitis caused by cyanoacrylate-based eyelash extension glues. 0000001536 00000 n 0000053193 00000 n Burkemper NM. 0000010096 00000 n Ask your HysterSisters. Perry AW, Sosin M (2009) Severe allergic reaction to Dermabond. Gonzalo-Garijo MA, Perez-Calderon R, Perez-Rangel I, Sanchez-Vega S, Constantino JA (2009) Contact dermatitis after orthopaedic surgery. : study design and supervision. 2020 Nov 1;43(6):e515-e522. Dermabond is a skin adhesive used to close wounds, according to FamilyDoctor.org 2. ), Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: a prospective, randomized intervention study, A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds, Allergic contact dermatitis to Dermabond after orthopaedic joint replacement, Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate, Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate, Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature, 10 years of patch testing with the (meth)acrylate series, Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives, Contact dermatitis to ethyl-cyanoacrylate-containing glue, http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4233b2_01.pdf. Postoperative dressing was performed with povidone-iodine, which was also used for preoperative skin preparation, at intervals of 23days for up to 2weeks after surgery. 6, 216222 (2014). 0000012232 00000 n Shim, J. S., Lim, T. K., Koh, K. H. & Lee, D. K. Surgical treatment of congenital hallux varus. Davis M, Stuart M. Severe allergic dermatitis to dermabond prineo, a topical skin adhesive of 2-octyl cyanoacrylate increasingly used in surgeries to close wounds. 0000013256 00000 n ), who has not used Dermabond since. The https:// ensures that you are connecting to the Its medical use quickly spread and interestingly, the first reported use of a cyanoacrylate tissue adhesive on the human eye occurred in 1968 [11]. Consequently, despite the advantages of topical skin adhesives, many orthopedic surgeons still hesitate to use them due to unpredictable adverse effects. Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports. It looks like iodine. Treatment is simple and most cases will resolve within a few weeks. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Although the use of topical skin adhesives has increased as an alternative to conventional skin closure methods, studies on the incidence and risk factors of ACD to topical skin adhesives have been limited. Emerg. Therefore, we thought that although females generally develop ACD more often than males, there is no sex difference in ACD that occurs after using 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. Disclaimer. YU==lmKgrk]=|>FWxMfhu89fdo{.KZJX_8x-.V)tI]B -+S5|r`(`i%u.h-QuK-Z[>>>>%k The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In this retrospective cohort study, we evaluated the incidence and characteristics of contact dermatitis (type IV hypersensitivity reaction) post application of Dermabond (Trade name PRINEO . J. Arthroplasty 28, 553556 (2013). Before Dermabond allergy is a rare event, but one that needs to be recognized and treated promptly. Dermabond is a liquid adhesive that contains the monomer of 2-octyl cyanocrylate (at a concentration of 94%). Orthopedics. Adv. Work as a cosmetician with regular exposure to cyanoacrylate-based eyelash extension glue has also been linked to occupational asthma and allergic rhinitis [27]. The substance was used as an industrial adhesive for metal, glass, rubber, and plastics since its introduction and eventually gained popularity in households as Superglue. Feature Flags: { Thus, the increasingly large number of hysterectomies being performed with traditional laparoscopic and robotically-assisted laparoscopic techniques may contribute to a gross underestimation of the actual number accomplished. Reconstr. in four of eight patients tested, and to 2-hydroxyethyl methacrylate in one of eight patients tested. A., Schwartz, T. A. If a superficial wound infection was suspected, oral antibiotics were administered. Given the case history, the patient was likely sensitized to Dermabond from prolonged exposure to embedded Dermabond from a previous procedure. Dunst KM, Auboeck J, Zahel B, Raffier B, Huemer GM (2010) Extensive allergic reaction to a new wound closure device (Prineo). Hysterectomy is one the most commonly performed surgeries in women in the United States. Physical examination of the surgical incision sites revealed that they were all clean dry and intact. 2022 Copyright OAT. The monomer polymerizes upon contact with the applicator tip, water, and exposure to body temperatures. The National Eczema Association says that people who have allergies to any of those things or if the skin is irritated by them may end up with a rash called contact dermatitis. Interv. Can DERMABOND PRINEO System cause blistering? Emerg. Clinical photograph of a patient showing well-demarcated pruritic eczematous eruption, papules, and vesicles that developed in the skin area to which topical skin adhesive was applied. In addition, previous studies investigating the incidence of 2-octyl cyanoacrylate topical skin adhesives did not conclude that females are a risk factor for developing ACD17,23,24. We retrospectively reviewed 1145 patients (739 patients with 2-octyl cyanoacrylate and 406 patients with n-butyl cyanoacrylate) who underwent skin closure with topical skin adhesives. 0000010011 00000 n This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department. Topical skin adhesives contained 2-octyl cyanoacrylate (Surgiseal, Adhezion Biomedical, Wyomissing, PA; Dermabond Prineo, Ethicon, Somerville, NJ) or n-butyl cyanoacrylate (LiquiBand, Advanced Medical Solutions, Winsford, UK). Join to Ask Your Questions and Receive Hysterectomy Checkpoints! HysterSisters.com is a massive online community with over 475,000 members and over 5 million posts. Care should be taken to apply Dermabond in thin layers to the edges of apposed skin with minimal seepage into the wound cavity. White, Andrew A. Concerns of tissue toxicity eventually excluded methyl 2-cyanoacrylate from use on human tissue [12]. 0000002861 00000 n HysterSisters.com is a massive online community with over 475,000 members and over 5 million posts. 0000020617 00000 n In fact, n-butyl cyanoacrylate is increasingly preferred for vascular embolization, bleeding hemostasis, or corneal injury repair over skin closure30,31,32. However, it should be noted that these figures only include those patients requiring inpatient hospitalization and do not capture same-day surgery. 1996 Jun;7(2):109-15. 6, 171177 (1999). 0000003512 00000 n ACD was considered as a dependent variable, while age, sex, body mass index, diabetes, smoking, asthma, history of atopic dermatitis, history of contact dermatitis, neutrophil count, eosinophil count, and anatomical region were considered as independent variables. Register Clinical Trials, Guidelines for OA Texts journals are led by prominent Wright JD, Ananth CV, Lewin SN, Burke WM, Lu YS, et al. Severe Allergic Contact Dermatitis to Dermabond Prineo, a Topical Skin Adhesive of 2-Octyl Cyanoacrylate Increasingly Used in Surgeries to Close Wounds. One-Stage Augmentation Mastopexy: A Review of 1192 Simultaneous Breast Augmentation and Mastopexy Procedures in 615 Consecutive Patients. My chart since then says allergic to adhesives and latex. For this reason, topical skin adhesives, which have the advantages of good scar cosmesis, infection prevention, easy skill acquisition, and lack of need for dedicated removal have begun to attract attention7,8,9,10,11,12,13. Contact Dermatitis. https://doi.org/10.1002/14651858.CD003326/epdf/full. The Bactrim DS was continued for one week because of the broken skin and the danger of superinfection. Did you have pelvic pain following your hysterectomy? (Log in options will check for institutional or personal access. Asahi, Rintaro 2nd ed. Is Fixing Pediatric Nail Bed Injuries With Medical Adhesives as Effective as Suturing? An area where the Dermabond had dripped on the lateral side of her breast was also erythematous. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. et al. sharing sensitive information, make sure youre on a federal Skin inflammation and pruritus abated completely within two days. Scott, G. R., Carson, C. L. & Borah, G. L. Dermabond skin closures for bilateral reduction mammaplasties: A review of 255 consecutive cases. The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study, Prospective, comparative clinical pilot study of cold atmospheric plasma device in the treatment of atopic dermatitis, Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions, Meta-analysis of the efficacy of preoperative skin preparation with alcoholic chlorhexidine compared to povidone iodine in orthopedic surgery, Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers, Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice, Bacterial sensitivity to chlorhexidine and povidone-iodine antiseptics over time: a systematic review and meta-analysis of human-derived data, http://creativecommons.org/licenses/by/4.0/, Contact Dermatitis in the Inpatient Hospital Settingan Updated Review of the Literature. 2022. Pediatr. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. Dermatitis 25, 99100 (2014). Jock itch and related conditions can cause discomfort and itchy, irritated skin. Quinn JV (2005) Tissue Adhesives in Clinical Medicine. Delmore, B. et al. It is a liquid that doctors apply on small wounds and skin surfaces to securely hold the edges together. Bitterman A, Sandhu K. Allergic contact dermatitis to 2-octyl cyanoacrylate after surgical repair: humidity as a potential factor. This can include contact with surgical instruments or supplies that are not hypoallergenic, such as bandages, surgical glue, or antiseptic solutions. Plast. Content may require purchase if you do not have access. Seven of 195 (3.6%) patients in Surgiseal, 13 of 544 (2.4%) patients in Dermabond Prineo, and nine of 406 (2.2%) patients in LiquiBand showed ACD. No history of previous extended contact with acrylate glues, such as Superglue, artificial nail or eyelash adhesives or dental treatment requiring use of adhesives. Although rare, cases of allergic contact dermatitis secondary to 2-octyl cyanoacrylate have been reported in the literature. The purpose of this study was to investigate the incidence and risk factors of ACD after the use of 2-octyl cyanoacrylate and n-butyl cyanoacrylate topical skin adhesives. Nunley, Julia She was afebrile and looked well. Three days postoperatively, she reported erythema around her incisions. Background: Careers. Close-up view of erythema surrounding the right lower abdominal 5-mm trocar site on post-operative day 7. Reconstr. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Plastic surgeons now use Dermabond for emergency room laceration repairs3 and for cosmetic surgery.4 Dermabond allows for the rapid closure of wounds while eliminating cross- and point-marks associated with suture closure. A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. A 36-year-old white woman on postoperative day four. and Fam. Sachse MM, Junghans T, Rose C, Wagner G (2013) Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. Did you have pelvic pain following your hysterectomy? Life Sci. Received date: May 07, 2018 Accepted date: May 23, 2018 Published date: May 28, 2018. This study has two limitations. HysterSisters.com is located at 111 Peter St, Toronto, Canada, M5V2H1 and is part of the VerticalScope network of websites. 0000008134 00000 n Chalmers et al.17 investigated 6008 patients who used 2-octyl cyanoacrylate topical skin adhesive for elective orthopedic surgery and reported an incidence 0.5% of ACD. Plast. See additional information. As inappropriate skin closure can lead to cosmetically unacceptable scars, delayed healing, wound dehiscence, or infection, selection of skin closure method is important for orthopedic surgeons1,2,3. 2015;73(4):195-221. ACD to topical skin adhesives usually presents as a self-limiting urticarial eruption near the incision site and subsides after proper local management. Krishnan, R., MacNeil, S. D. & Malvankar-Mehta, M. S. Comparing sutures versus staples for skin closure after orthopaedic surgery: systematic review and meta-analysis.
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