PMC Polymorphous light eruption is a rash caused by sun exposure in people who have developed sensitivity to sunlight. This exposes the skin to small doses of UVA or UVB light that helps your skin be less sensitive to light. Is there a generic alternative to the medicine you're prescribing me? Keywords: [2], The photosensitivity connected with lupus erythematosus is the main condition that may appear like PLE. 2. Your healthcare provider can suggest ways to protect your skin from UV light and prevent PMLE. Unable to load your collection due to an error, Unable to load your delegates due to an error. Polymorphous light eruption (PLE) is a common skin rash that occurs due to sunlight exposure. Your skin can build up a tolerance to UV light throughout the summer, but this will go away during the winter. Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening. There are many clothing choices that can help you do this, such as: Polymorphous light eruption is a condition that causes your skin to react to light, usually UV light. A skin biopsy, or tissue sample, may be obtained to confirm the diagnosis. However, positive antinuclear antibody and extractable nuclear antigen (anti-Ro/La) in low titer may be detected, even in the absence of other criteria to suggest a diagnosis of lupus erythematosus. What to wear to protect your skin from the sun. Careers. [CDATA[ It often reduces in severity over time and eventually resolves with a lower prevalence in older people. Accessed Dec. 9, 2021. 2023 Healthline Media LLC. Dermatologic clinics. Plasmacytoid dendritic cells and T regulatory cells predominate. [10] Further episodes of the irritable rash occur several hours to days following subsequent sun exposure. Its important to note that, while UVA exposure is the typical cause, the rash can be a result of UVA or UVB exposure. Outline the treatment and management options available for polymorphic light eruption. Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. Your provider may refer to this as hardening the skin. You should only attempt this type of desensitization while under your providers care. Its most common among: Polymorphous light eruption typically presents as an itchy rash on sun-exposed areas of your body. You should reapply every 2 hours. This condition causes a red, itchy rash to form soon after youve been in the sun or exposed to artificial UV rays. PMLE is characterized by recurrent, abnormal, delayed reactions to sunlight, ranging from erythematous papules, papulovesicles, and plaques to erythema multiforme -like lesions on sunlight-exposed surfaces. Reactions to physical agents. Phototherapy Seborrheic dermatitis commonly affects the skin on the chest, causing a red, scaly rash to appear. All rights reserved. Call a healthcare provider if you develop an unexplained skin rash or changes to your skin. What tests do I need? Polymorphous light eruption (PLE) is the commonest immuno-mediated photodermatosis. Photodermatol Photoimmunol Photomed. It may persist for weeks or months if repeatedly exposed, although in most individuals gradual exposure leads to hardening so that the eruption does not occur in late summer. The eruption is treated with topical corticosteroids with some benefit in reducing symptoms and duration. Because PMLE is more prevalent in women than men, it is hypothesized that there is a hormonal component to its pathogenesis. Polymorphic light eruption pathology codes and concepts, Juvenile spring eruption of the ears. Epub 2010 Jul 8. van de Pas CB, Kelly DA, Seed PT, Young AR, Hawk JL, Walker SL. Heat rash is a painful condition that occurs in hot weather when sweat pores become blocked. This condition causes a red, itchy rash to form soon after you've been in the sun or exposed to artificial UV rays. This content does not have an English version. Polymorphous light eruption (PMLE) is a common skin rash that develops after exposure to ultraviolet (UV) light. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Polymorphic light eruption. Four times more common in women than men. 60% of patients yielding a positive eruption are clinically and. PLE is a relatively common skin disorder that is not easy to diagnose or manage. Accessibility The rash typically lasts only 23 days, but some people may continue having symptoms throughout summer. An official website of the United States government. It can be mildly to markedly pruritic and general malaise, headache, fever, and nausea can occur in rare cases. When the condition first appears, the most common symptoms include: The rash will then appear on parts of the body that have had sun exposure, such as the: Some people also experience additional symptoms around 4 hours after sun exposure, such as: These additional symptoms typically last for only 12 hours. https://melanomafoundation.org/melanoma-prevention. [16], In the United States, whilst one-quarter of people being investigated for a photosensitivity disorder were diagnosed with PLE, the prevalence in the general population is 10 to 15% and may even be as high as 40% as suggested in one study of more than 2000 people. 2008. FOIA PLE symptoms typically appear around 2 hours after sun exposure and last for several days before improving on their own. Direct immunofluorescence testing is negative. Your health care provider can probably make a diagnosis of polymorphous light eruption based on a physical exam and your answers to questions. Your health care provider might have you undergo laboratory tests in order to confirm a diagnosis or rule out other conditions. It can feel sore or burning. The rash usually appears as tiny, inflamed bumps or slightly raised patches of skin. Skin diseases due to physical and chemical causes", https://en.wikipedia.org/w/index.php?title=Polymorphous_light_eruption&oldid=1127125983, Skin conditions resulting from physical factors, Pages containing links to subscription-only content, Creative Commons Attribution-ShareAlike License 3.0, Shortly after sun exposure in people younger than age 30-years, This page was last edited on 13 December 2022, at 01:14. 1 mo. [22], Generally, PLE resolves without treatment; also, PLE irritations generally leave no scar. Join. Endogenous estrogen exacerbates UV-induced inflammation and photoaging in mice. [3] The bumps may become small blisters or plaques and may appear bloody,[3]often healing with minimal scarring. Wolf P, Gruber-Wackernagel A, Bambach I, et al. 8600 Rockville Pike PMLE can appear on any part of your body exposed to UV light, although it rarely appears on your face. Polymorphous light eruption: A clinical, photobiologic, and follow-up study of 110 patients. Most UV light you are exposed to comes from the sun. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Treatment for burn blisters: Debride or leave intact? FOIA We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. The eruption is usually symmetrically distributed in a patchy fashion and typically does not involve all of the exposed skin. A positive family history in some patients suggests a genetic risk factor. The cause of polymorphic light eruption is unknown. Lembo S, et al. Polymorphic light eruption, Author(s): Dr Prudence Gramp, Dermatology Department, Gold Coast University Hospital, Australia. It is primarily caused by either UVA (7590%) or UVB light alone or UVA and UVB light concurrently, UVA can penetrate window glass and some sunscreens do not protect against it. Gradual hardening is one form of treating PMLE. PMLE may be lifelong although 60% of people see improvement or resolution over 15 years and 75% of people in 30 years. [2], Another treatment option is a supervised course of low dose phototherapy, usually undertaken in winter. It occurs after solar or artificial UV-light exposure and affects only the sun-exposed areas with preference of the V-area of the chest, of arms and forearms, legs, upper part of the back, and rarely the face. Polymorphous light eruption (PLE) presents with itchy red small bumps on sun-exposed skin, particularly face, neck, forearms and legs. Current theories involve two steps that lead to a polymorphous light eruption. Management requires determining what provokes the eruption and then attempting to minimize this, while at the same timegradually increasing exposure to induce hardening. 13th ed. It typically comes back each year when a person begins to have more sun on their skin. [7][8](Level V), Gruber-Wackernagel A,Byrne SN,Wolf P, Polymorphous light eruption: clinic aspects and pathogenesis. The rash may first appear in the spring and diminish as the spring and summer months progress. J Invest Dermatol. [6], People vary in the amount of sun exposure needed to trigger the rash. It is one of the most common sun-related skin problems and is most common among women and among people from northern climates who are not regularly exposed to the sun. She spent most of her time on the beach, in the shade. Whether administration of estrogen in the form of oral contraceptives or postmenopausal replacement therapy might induce high ANA levels in a healthy individual cannot be ascertained from our data. If the symptoms do not improve or are severe, a doctor may prescribe: Because people get vitamin D from the sun, people with PLE can be more at risk for vitamin D deficiency. What treatments are available, and which do you recommend? Consider wearing clothing designed to provide sun protection. Using high SPF, broad-spectrum sunscreen, and wearing protective clothing helps minimize UV light exposure. The eruption can appear within hours of sun exposure and last for days. A provocative test in which UV radiation is used to confirm the diagnosis. Majoie IML, van Weelden H, Sybesma IM, Coenraads PJ, Sigurdsson V. Polymorphous light eruption-like skin lesions in welders caused by ultraviolet C light. PMLE is a delayed hypersensitivity reaction in the skin to unknown endogenous cutaneous photo-induced antigens. Last reviewed by a Cleveland Clinic medical professional on 02/20/2023. 2023 Healthline Media UK Ltd, Brighton, UK. Polymorphous light eruption (PMLE) is an allergic reaction to sunlight or other sources of ultraviolet (UV) light. Careers. Polymorphous light eruption (PMLE) is a common skin rash generally caused by exposure to the suns ultraviolet (UV) light. Read on to learn more about PLE, including the symptoms, causes, and treatments. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation. The hardening effect, where further exposure to UV prevents the eruption, is not fully understoodand could involve tanning, hyperkeratosis, and acanthosis of the epidermis, and/or the development of immunological tolerance. In Germany the female to male ratio has been cited as 9:1. PLE is considered as a delayed hypersensitivity response to newly UV induced, but still unidentified, antigen(s). It is also known as polymorphous light eruption, sun allergy, sun poisoning, prurigo aestivalis, summer eruption/prurigo, or eczema solare. Its possible that UV radiation alters a compound in your skin and your immune system reacts to the new compound. Frontiers in medicine. Ultraviolet-radiation-induced erythema and suppression of contact hypersensitivity responses in patients with polymorphic light eruption.
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