In traditional medicine, justicia carnea is used in treating hepatitis. Furthermore, increased MID by the extracts could indicate macrophage formation ability and pathogenic scavenging role. There are several claims that justicia carnea can prevent epilepsy and convulsion among children. For some, the boiling method is preferred while for others, soaking in hot water is more convenient. But like in the case of depression and hepatitis, other species of justicia have been studied and proven to be antiepileptic. Prevent this by spraying the leaves with water. Pot the specimen and bring it indoors to add a bright touch of color to your interiors. J Nat Prod 1988;51(4):804-805. Create a beautiful garden with this colorful and Use our interactive toolsto design your dream garden. de Smet, P. A. The plant produces dark green leaves around 8 inches in length. Inter J Pharm Sci Res. Anal Biochem. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. Rich, well-drained soil retaining ample moisture is the perfect home for Brazilian plume flowers. Olaniyan JM, Hadiza LM, Hussaini AM, Musa BB, Abubakar SA. Different researches performed on wistar rats has proven the non toxicity of justicia carnea. 2016;4(1):5360. 3. This is in agreement with study of Anthonia et al., [21] who obtained LD50 above 5000mg/kg for aqueous extracts of J. carnea leaf. This may be because of its hepatoprotective activity. Chemical constituents and biological activities of species of Justicia a review. Organic extract of Justicia pectoralis Jacq. Justicia carnea (belonging to Acanthaceae family) is a flowering plant consisting ~600 species that are widely distributed in the tropics and subtropics [7]. There should be further studies on the antidepressant activity of justicia carnea leaves. Antioxidants & redox signaling Forum Review. Note this is the default cart. Nunes TRS, Cordeiro MF, Beserra FG, et al. The significant decrease in kidney GSH at 1200mg/kg could be due to ample dietary bioactive constituents in the extract that requires frequent conjugation of GSH in the cell or oxidation to oxidized glutathione (GSSG). https://doi.org/10.1016/j.biocel.2006.07.001. If you provide us with your name, email address and the payment of a modest $25 annual membership fee, you will become a full member, enabling you to design and save up to 25 of your garden design ideas. Another strong benefits of justicia carnea leaves is in lipid profile. Clinical Guide to Laboratory tests. J Afr Ass Physiol Sci. Add organic matter or compost in the soil and place the plant. By using this website, you agree to our Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. Part of In various parts of Africa, several species of Justicia are used in traditional medicine for the treatment of anemia, inflammation, fever, diarrhea, liver diseases and arthritis respiratory and gastrointestinal disorder [8, 9]. [4].Inflammationinjuries, in an attempt to heal is presented by five cardinal signs of heat (calor), redness (rubor), swelling (tumor), pain (dolor) and loss of function5.Studieshave demonstrated inflammation as being caused by . DOI: https://doi.org/10.1089/ars.2007.1901. Meth Enzymol. Names of Justicia Betonica in various languages of the world are also given. How long does it take for Aju mbaise to work. While histology of organs showed no adverse pathological lesions in the internal organs of rats, higher dose (1200mg/kg) over a period of time could cause noticeable liver and kidney injury. The protein content may help in cellular functions and are building blocks for structural and functional biomolecules. J Nat Prod 1988;51(3):599-600. View abstract. The principle is based on the formation of coloured complex when protein peptide interacts with cupric ions in an alkaline medium. CAS You can add milk or honey for taste before drinking. It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Paes-Leme AA, Motta ES, De Mattos JCP. 50mg/kg-1200mg/kg treatments relative to control showed varied degree of hepatic injury that is dose dependent. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. Effect of Tectona grandis on phenylhydrazine induced anemia in rats. Therefore,it is imperative to investigate the effects of the plant on the essential biochemical indices in diabetic rats so as to establish its safety. The catalase activity was calculated using the expression: Note: A=change in absorbance, TV=total volume, TP=total protein, SV=sample volume, =molar extinction=40M1 cm1. Great for use as a foundation or mass planting, it is also terrific for containers or as a houseplant. Onoagbe IO, Attah V, Luther MM, Esekheigbe A. Hypoglycemic and anti-diabetic effects of Morinda lucida and Tetracera alnifora in normal and streptozotocin-induced diabetic rats. Tips on how to get rid of leaf eating caterpillar. Fertility leaves: Benefits and side effects, Guava Leaf Tea: Health Benefits of Guava Leaves, Coriander seeds: 18 benefits Coriandrum sativum fruits and seeds, Rapini: Nutritional facts, benefits, side effects and care. Powdered sample (1000g) was soaked in absolute ethanol (3000mL) with constant stirring. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. Justicia carnea has been used in traditional medicine to treat diabetes. Filed in Biochemistry Project Topics, Current Projects by TMLT Editorials on September 22, 2020. PubMed It is also known as Jacobinia carnea, and is a part of the Acanthaceae family along with the Aphelandra squarrosa (Zebra plant) and Crossandra. Read also (Cashew leaves: health benefits and side effects of Anacardium occidentale). Saunders; 1995. p. 26873. Check these Great Plant Combination Ideas with Justicia, Eye-Catching Retaining Walls and Staircases, An Eye-Catching Mediterranean Garden with Agave, Aloe and Pincushion, A Striking Water-Wise Border with Agave, Cactus and Ocotillo, A Beautiful Duo with Agave 'Blue Flame' and 'Blue Glow', A Long-Lasting Summer Garden Idea with Marigold and Sage, 8, 9, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, H1, H2. Ewe eje is a rich source of phytochemicals, minerals and vitamins. Make sure to follow the package instructions carefully. The flowers are slightly fragrant and mostly sterile. Eyong EU, Umoh IB, Ebong PE, Eteng MU, Antai AB, Akpa AO. 16. Histopathological examinations of sections of the liver collected from the 4 Free radicals and antioxidants in normal physiological functions and human disease. Corra, GM., de C. Alcntara, AF. degree in Biochemistry from Olabisi Onabanjo University, Ago-iwoye, and University of Ibadan, Ibadan, Nigeria respectively. Cut from the stem, some fresh or dried Justicia carnea leaves. It may also affect the activity of hormones. Lipid peroxidation was determined by measuring the formation of thiobarbituric acid reactive substances (TBARS) according to the method described by Buege and Aust [20]. The findings back up local assertions that they can be. CAS View abstract. Despite the use of Justicia carnea and other reported scientific studies, there are no reports on its effects on the major organs of the body. Biomed Res. Acute and chronic toxicity of the aqueous extract of Artemisia afra in rodents. The hematopoietic systems represent a sensitive target of toxic compounds and an essential index of physiological and pathological status in experimental animals [24]. Ewe eje is good for the liver. The resultant liquid after boiling is usually crimson red. There may be some problems if the air is too dry in winter. Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Google Scholar. Over time, they cause atherosclerosis and myocardia infarction. Liver and kidney in all treated groups maintained similar activities of catalase (CAT) compared to the control. The antidiabetic effect of justicia is through the inhibition of-amylase and -glucosidase, the carbohydrate metabolizing enzymes, and also through its hypolipidemic potential. By entering your email address you agree to receive a daily email newsletter from Plant Care Today. A cup of ewe eje extract in the morning will provide you with energy needed to pull through the days activities. The minerals present in justicia carnea (Ewe eje or ogwu obara) are calcium, iron, magnesium, copper and zinc. MacRae, W. D. and Towers, G. H. Justicia pectoralis: a study of the basis for its use as a hallucinogenic snuff ingredient. Effect of methanol leaf extract of Justicia carnea on serum albumin (ALB) and total protein (TP) concentration CCl 4 intoxicated rats. Phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis indicated presence of . This claim have not been verified. Acute toxicity was determined in two phases using Lorke method. Not sure which Justicia to pick?Compare All Justicia. It also grows in some Caribbean islands, including Trinidad and Tobago. All rights reserved. Author ESA managed the literature searches and wrote the first draft of the manuscript with the assistant of FOA. In a pot, pour in a cup of water and bring to a boil. Anaemia is a common blood disorder that affects people of all ages, though people at greater risk are the elderly, young women and infants. II. Ewe eje or Ewe ajeri is known by the Igbo tribe as Ogwu obara. Ogwu obara is commonly used in making porridge yam, and soups. 1. Macrocytic and hypochromic anemia usually results due to increased mean corpuscular volume (MCV) and decrease in mean corpuscular hemoglobin concentration [30]. In the study conducted by Onyeabor and his colleagues, it was shown that the leaf extract not only reverses anemic condition, but also lowered the lipid profile of the experimental rats. These minerals help in boosting blood production, which is why the plant is called ogwu obara (blood medicine) among the Igbo people of Southern Nigeria. Mr. E.S. Keep the soil moist, but not waterlogged. The reference cuvette contained 2.95ml buffer, 0.03ml of substrate (epinephrine) and 0.02ml of water. In its native habitat, the Justicia carnea plant grows upright and may reach 3 5 feet tall. Based on estimation by World Health Organization (WHO), larger percentage (between 80 and 90%) of the worlds population especially in developing countries depends on traditional system of medicine [1, 2]. Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. In this study, nutritive potentials and effects of aqueous extract of Justicia carnea leaves on biochemical indices of anaemic male Wistar albino rats were investigated. Nutritional Composition of Ewe eje (Justicia carnea leaf). Locklear, T. D., Huang, Y., Frasor, J., Doyle, B. J., Perez, A., Gomez-Laurito, J., and Mahady, G. B. Estrogenic and progestagenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS. When the Jacobinians are newly planted, water them daily for a few weeks. Ewe eje is mainly given to persons who want a blood boost such as pregnant women, persons suffering from anemia and other convalescents. However, the mechanism by which phytochemicals act as prooxidants in-vivo is still under investigation [25]. J Ethnopharmacol. View abstract. A total number of forty two (42) male albino rats weighing between 120 and 170g were used in this study. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. Rats were routinely observed for signs of toxicity. 200, 500 and 1000 mg/kg bw of Justicia carnea showed a significant (p<0.05) decrease in the activities of ALT, AST and ALP, and bilirubin level while total protein and albumin levels increased significantly (p<0.05) when compared with the rats treated with CCl alone. Differences between means were considered to be significant at (p<0.05) using LSD (Least Square Difference) post hoc test. Superoxide dismutase (SOD) activities were elevated across all doses in the liver with significant (p<0.05) difference only observed in the highest dose (1200mg/kg) while kidney showed no significant difference compared to the control. 400). Accept Article It is very rich in iron, a major component is RBC hemoglobin. The higher LD50 (>5000mg/kg body weight) of J. carnea leaf ethanol extract suggested that the ethanol extract is experimentally safe and not toxic. Blooming from early summer to fall, the flowers are attractive to hummingbirds and butterflies. Elevated activity of catalase in liver and kidney across tested doses of J. carnea ethanol extract showed no significant effect compared to the control. In phase I, rats were randomized into 3 groups of 3 rats per group. van Andel T., Carvalheiro LG. They protect our cells from the harmful effects of reactive oxygen species. It is believed by local consumers in Ghana to possess anti-anaemic effects that boost blood levels in pregnant women, anaemic patients and also . Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). He is a research assistant in the Biochemistry Unit of the same Department. However, serious caution of the dose should be taken into consideration when extrapolating this result for human consumption. The indistinguishable differences of total protein in the liver and kidney of rats treated with ethanol extract of J. carnea could indicate that the plant extract did not alter protein synthetic function of the organs. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. Be sure to follow relevant directions on product labels and consult your, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. J Acute Disease. They range in colors such as red, orange, mauve, magenta, apricot, and pink. PubMed Central The levels of white blood cell count, lymphocyte, granulocyte and MID could indicate that ethanol extract of J. carnea leaf pose no toxicity or sub acute inflammation to the overall defense mechanism and immunity of the experimental rats. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow). Control treatment showed normal central venules without congestion, the morphology of the hepatocytes appear normal, the sinusoids appear normal with no observable form of infiltration and no observable pathological lesion seen. The absorbance of the supernatant was measured against reagent blank at 532nm. Fitoterapia. Safety assessment of Uvaria chamae root extract: acute and subchronic toxicity studies. Leaf extract in isoproterenol induced myocardial infarction in albino rats. Technical guidelines assembly of veterinary medicine research. Prepare the existing soil by breaking it up with a spade or hoe. 2012;9(1):817 https://doi.org/10.4314/ajtcam.v9i1.12. They should be watered regularly (once per week), but not overwatered. degree in Biochemistry fromUniversity of Ado-Ekiti, Ekiti State, Nigeria and University of Ibadan, Nigeriarespectively. 2013;1:38898. OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. Justicia carnea and Cnidoscolus aconitifolius were tested for their capacity to ameliorate the fecundity of chloramphenicol-induced lymphoma in rats. These compositions (metabolites and nutrients) are all responsible for the medicinal value and the health benefits of Justicia carnea. The red coloration of the decoction made people think that the plant must contain blood boosting compounds. The principle is based on the reduction of dichromate in a weak acid medium (acetic acid) to chromic acetate which is further heated in the presence of hydrogen peroxide to form an unstable intermediate (perchromic acid) that can be monitored spectrophotometrically at 620nm. Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea. The possible anti-anaemic property of the leaf could be linked to the improved hemoglobin, PCV and RBC observed in this study. Justicia carnea (ewe eje) is used by pregnant women to boost the production of red blood cells and cure anemia in pregnancy. J Ethnopharmacol. In this article i will take you through the nutritional and medicinal benefits of justicia carnea. Rich on haematological and biochemical parameters in healthy Wistar rats. Antianaemic potentials of some plant extracts on phenyl hydrazineinduced anemia in rabbits. This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. Article These compounds beyond boosting your blood concentration, thereby enhancing the transport of nutrients to various parts of the body, also boost your immune system against several infectious diseases. Vitamin C and E are antioxidants. The unique and beautiful tubular flowers of Justicia carnea highlight the plant. There are several scientific studies which show that the methanolic leaf extract of Justicia carnea protects the liver from toxic effect of carbon tetrachloride harmful effect on the live integrity and functions. It has been shown also that other specie of justicia improve central nervous system functions and health and protect it from toxic damages. Information from this source is evidence-based and objective, and without commercial influence. From this study, the significant increase in platelet counts suggested that the extract could be useful in preventing excessive blood loss (through blood clotting) and resistance of capillary membranes to leakage of red cells when blood vessels are damaged. The acute toxicity test also proved that justicia carnea leaves are safe for consumption. Further study assessing the kidney indices (urea, creatinine and electrolytes) is however encouraged to ascertain the safety of the plant extract on renal function. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. In this study, the aqueous leaf extract of Justicia carnea was used. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). The flowering Justicia plant is a perennial native to the Atlantic Forest eco-regions in eastern Brazil. When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. They also maintain our skin tone and texture, and help in reproductive functions. J Am Diet Assoc. View abstract. The spectacular rosy plumes of the flamingo-colored flower are distinctive and attract hummingbirds to pollinator gardens. The absorbance was taken at interval of 1min for 3min at 480nm. 2023 BioMed Central Ltd unless otherwise stated. However, coadministration of both extracts exerts a synergistic effecton the . In some areas, the plant may tolerate temperatures as low as 50 degrees Fahrenheit (10 C). The aqueous leaf extract of ewe eje has demonstrated hypoglycaemic and antidiabetic properties; and thus, can be said to assist with blood sugar levels reduction. Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. BMC Complem Altern Med. Washington, DC: The National Academies Press; 1997. https://doi.org/10.17226/4988. and M.Sc. The major use of Justicia carnea leaves is to improve blood production. Safety assessment of oral administration of ethanol extract of, $$ \mathrm{Total}\ \mathrm{protein}\kern0.5em =\kern0.5em \frac{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{sample}}{\mathrm{Absorbance}\ \mathrm{of}\ \mathrm{standard}}\kern0.5em \times \kern0.5em \mathrm{Concentration}\ \mathrm{of}\ \mathrm{standard} $$, $$ \mathrm{Catalase}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}\right)=\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{SOD}\ \mathrm{activity}\ \left(\mathrm{U}/\mathrm{ml}/\mathrm{mg}\ \mathrm{protein}\right)\kern0.5em =\kern0.5em \frac{\Delta \mathrm{A}/\min \kern0.5em \times \kern0.5em \mathrm{TV}}{\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, $$ \mathrm{Concentration}\kern0.5em \mathrm{of}\kern0.5em \mathrm{reduced}\kern0.5em \mathrm{GSH}\kern0.5em =\kern0.5em \frac{\left(\Delta \mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\left(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}\right)} $$, $$ \mathrm{Malondialdehyde}\kern0.5em =\kern0.5em \frac{\left(\mathrm{A}\kern0.5em \times \kern0.5em \mathrm{TV}\right)}{\Big(\upvarepsilon \kern0.5em \times \kern0.5em \mathrm{SV}\kern0.5em \times \kern0.5em \mathrm{TP}} $$, https://doi.org/10.1186/s40816-020-00234-4, https://doi.org/10.1016/j.jep.2015.06.005, https://doi.org/10.1016/j.joad.2015.08.006, https://doi.org/10.1016/j.jep.2005.06.013, https://doi.org/10.3109/08860220903367585, https://doi.org/10.1590/S0102-695X2011005000196, https://academicjournals.org/journal/AJPS/article-full-text-pdf/6AA410310867, https://doi.org/10.35841/biomedicalresearch.30-18-666, https://doi.org/10.1016/j.jep.2007.02.011, https://doi.org/10.1186/s40816-019-0104-4, https://doi.org/10.1016/j.fitote.2008.02.005, https://doi.org/10.1016/j.jada.2008.06.430, https://doi.org/10.1016/j.biocel.2006.07.001, https://doi.org/10.1186/s12906-015-0760-y, http://creativecommons.org/licenses/by/4.0/. 2003;84:99104. Arch Toxicol. Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). Studies on the Phytochemical and Nutritional Composition of Aqueous Leaf Extract of Justicia Carnea and its Effect on Some Biochemical Parameters in Anaemic Rats. The cuttings should be placed in individuals pots and put under glass or shaded location, away from direct sunlight. It is a creeping, perennial plant and grows up to 2 meters tall. Join now and start creating your dream garden! Consumption of medicinal plants without scrutinizing its efficacy and safety can result in unexpected toxic effects resulting in physiology changes of different organs in the body.
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